Choosing a GUI framework is a critical decision for any Python project. Two of the most popular choices are Tkinter and PySide. Here's how they stack up.
Ease of Use and Learning Curve

Tkinter is built into Python, making it incredibly easy to get started. However, creating complex, modern-looking layouts can be challenging and time-consuming. This is its primary weakness.

PySide is more powerful out-of-the-box and uses a widget-based system that can feel more modern. However, it has a steeper learning curve and requires a separate installation.
Both Tkinter and PySide are included in our Pro version as well as other Python Libraries such as Kivy, Flet and Custom Tkinter
The TkinterBuilder Advantage
TkinterBuilder is designed to eliminate Tkinter's biggest weakness. By allowing you to design visually, it makes creating complex layouts even easier than with PySide, while retaining the simplicity of Python's standard library.
Licensing
Tkinter and PySide is free to use in any project, personal or commercial.
Conclusion
For projects that require a quick start, no licensing fees, and a simple distribution, Tkinter is an excellent choice. With a tool like TkinterBuilder to handle the UI design, its main disadvantage is removed, making it a powerful contender for professional applications.